(反式)-1,1'-(1,2-环丙烷二基)二苯合成路线 （共 61 条）
反应条件
1: 1) n-BuLi / 1) THF, -78 deg C, 2) -78 to 20 deg C, 1 h
2: n-BuLi / tetrahydrofuran / 0.7 h / -78 °C
View Scheme
参考文献
Krief, Alain; Hobe, Myriam; Dumont, Willy; Badaoui, Elie; Guittet, Eric; Evrard, Guy
Tetrahedron Letters, 1992 , vol. 33, # 23 p. 3381 - 3384
反应条件
1: 98 percent / pyridine / 2 h
2: sodium ethoxide / ethanol / 1.5 h
3: 11 percent / sodium / pentan-1-ol / Ambient temperature; overnight
4: 1. methyl lithium; 2. nitrosyl chloride / 1. ether, 5 min; 2. dimethoxyethane, 5 min
5: sodium hydroxide, sodium dithionite / aq. ethanol / 2.5 h / 62 °C
View Scheme
参考文献
Powell, Burwell F.; Reichenthal, Jules; Overberger, C. G.; Anselme, J.-P.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 219 - 224
反应条件
1: 58 percent / thionyl chloride / 0.5 h / Heating
2: sodium ethoxide / ethanol / 1.5 h
3: 11 percent / sodium / pentan-1-ol / Ambient temperature; overnight
4: 1. methyl lithium; 2. nitrosyl chloride / 1. ether, 5 min; 2. dimethoxyethane, 5 min
5: sodium hydroxide, sodium dithionite / aq. ethanol / 2.5 h / 62 °C
View Scheme
参考文献
Powell, Burwell F.; Reichenthal, Jules; Overberger, C. G.; Anselme, J.-P.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 219 - 224
反应条件
1: sodium ethoxide / ethanol / 1.5 h
2: 11 percent / sodium / pentan-1-ol / Ambient temperature; overnight
3: 1. methyl lithium; 2. nitrosyl chloride / 1. ether, 5 min; 2. dimethoxyethane, 5 min
4: sodium hydroxide, sodium dithionite / aq. ethanol / 2.5 h / 62 °C
View Scheme
参考文献
Powell, Burwell F.; Reichenthal, Jules; Overberger, C. G.; Anselme, J.-P.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 219 - 224
反应条件
1: 1. methyl lithium; 2. nitrosyl chloride / 1. ether, 5 min; 2. dimethoxyethane, 5 min
2: sodium hydroxide, sodium dithionite / aq. ethanol / 2.5 h / 62 °C
View Scheme
参考文献
Powell, Burwell F.; Reichenthal, Jules; Overberger, C. G.; Anselme, J.-P.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 219 - 224
反应条件
1: 11 percent / sodium / pentan-1-ol / Ambient temperature; overnight
2: 1. methyl lithium; 2. nitrosyl chloride / 1. ether, 5 min; 2. dimethoxyethane, 5 min
3: sodium hydroxide, sodium dithionite / aq. ethanol / 2.5 h / 62 °C
View Scheme
参考文献
Powell, Burwell F.; Reichenthal, Jules; Overberger, C. G.; Anselme, J.-P.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 219 - 224
反应条件
1: 85 percent / sodium nitrite / acetic acid; H2O / 1. 0.5h, 0 degC; 2. r.t., 33h
2: sodium hydroxide, sodium dithionite / aq. ethanol / 2.5 h / 60 °C
View Scheme
参考文献
Powell, Burwell F.; Reichenthal, Jules; Overberger, C. G.; Anselme, J.-P.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 219 - 224
反应条件
1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water; toluene / 2 h / 70 °C / Inert atmosphere
2: tetrakis-dirhodium(II)-N-perfluorooctylsulfonyl-L-prolinate / tetrahydrofuran; toluene / 20 °C / Inert atmosphere
View Scheme
参考文献
Verdecchia, Mirella; Tubaro, Cristina; Biffis, Andrea
Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1136 - 1139
反应条件
1.1: diethylzinc; trifluoroacetic acid / dichloromethane / 1.33 h / 5 °C
1.2: 36 h / 5 - 20 °C
2.1: C3H6C9H10N4 / N,N-dimethyl-formamide / 90 h / 20 °C / Inert atmosphere; UV-irradiation
View Scheme
参考文献
Cahard, Elise; Schoenebeck, Franziska; Garnier, Jean; Cutulic, Sylvain P. Y.; Zhou, Shengze; Murphy, John A.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 15 p. 3673 - 3676
反应条件
1: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere; UV-irradiation
2: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere; UV-irradiation
View Scheme
参考文献
Cahard, Elise; Schoenebeck, Franziska; Garnier, Jean; Cutulic, Sylvain P. Y.; Zhou, Shengze; Murphy, John A.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 15 p. 3673 - 3676
