2,6-二甲基吡啶-4-羧酰胺合成路线 （共 7 条）
反应条件
pyridine; trifluoroacetic anhydride in dichloromethane T=0°C; 24 h;
参考文献
Bolli, Martin; Lescop, Gyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat
Patent: US2011/46170 A1, 2011 ;
Location in patent: Page/Page column 20 ;
反应条件
hydrogenchloride in methanol
参考文献
G.D. SEARLE and CO.
Patent: EP1221441 A2, 2002 ;
Location in patent: Page 41 ;
反应条件
ammonia in methanol
T=60°C; 20 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2009/109907 A1, 2009 ;
Location in patent: Page/Page column 50 ;
WO 2009/109907 A1
反应条件
sodium hydroxide; dihydrogen peroxide in ethanol; water
T=0°C; 0.5 h;
参考文献
G.D. SEARLE and CO.
Patent: EP1221441 A2, 2002 ;
Location in patent: Page 41, 203 ;
反应条件
1.1: anhydrous tetramethylammonium chloride; trichlorophosphate / 16 h / 130 °C
1.3: pH 7 - 8
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; 1,4-dioxane / 18 h / 75 °C / Inert atmosphere
3.1: ammonia / methanol / 20 h / 60 °C
View Scheme
参考文献
Bolli, Martin; Lescop, Gyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat
Patent: US2011/46170 A1, 2011 ;
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; 1,4-dioxane / 18 h / 75 °C / Inert atmosphere
2: ammonia / methanol / 20 h / 60 °C
View Scheme
参考文献
Bolli, Martin; Lescop, Gyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat
Patent: US2011/46170 A1, 2011 ;
反应条件
T=180 - 190°C; 22 h; Product distribution;
参考文献
Hirota, Takashi; Namba, Tetsuto; Sasaki, Kenji
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 949 - 953
