反应条件
1: (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride With 4-(N,N-dimethlyamino)pyridine; triethylamine; methyl chloroformate in ethyl acetate T=20 - 30°C; 1 h; 2: methanol in ethyl acetate T=20°C; 2 h; Product distribution / selectivity;
参考文献
KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO
Patent: WO2008/34912 A2, 2008 ;
Location in patent: Page/Page column 45 ;