外消旋5,6-去氢普瑞巴林合成路线 (共 2 条)
反应条件
1: With sodium hydroxide; bromine in water T=5 - 40°C; 0.5 h; 2: With sulfuric acid in 2-methyl-propan-1-ol; water T=30 - 33°C; pH=3; 3: With tributyl-amine in 2-methyl-propan-1-ol T=0 - 20°C; 1 h;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICAL USA, INC.
Patent: WO2009/46309 A2, 2009 ;
Location in patent: Page/Page column 15-17 ;
反应条件
1: With sodium hydroxide; bromine in water T=5 - 35°C; 2: With sulfuric acid in 2-methyl-propan-1-ol; water T=35°C; pH=0.5 - 3; 3: With tributyl-amine T=0 - 20°C; 2 - 8 h;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICAL USA, INC.
Patent: WO2009/46309 A2, 2009 ;
Location in patent: Page/Page column 18 ;