5-甲基-2-苯基-2H-吡唑-3-羧酸合成路线 （共 8 条）
反应条件
1: With sodium hydrogencarbonate in methanol T=0 - 60°C; 2 h; 2: With sodium hydroxide in methanol; water T=80°C; 2 h; 3: With hydrogenchloride in methanol; water pH=3;
参考文献
Journal of Agricultural and Food Chemistry, , vol. 59, # 6 p. 2456 - 2461
反应条件
n-butyllithium; diethyl ether anschliessend mit festem CO2;
参考文献
Journal of the American Chemical Society, , vol. 74, p. 3243,3245
反应条件
1: acetic acid 2: KOH; ethanol; water View Scheme
参考文献
Journal of the Chemical Society, , p. 3259,3262
反应条件
potassium hydroxide; ethanol; water
参考文献
Journal of the Chemical Society, , p. 3259,3262
反应条件
1: acetic acid 2: KOH; ethanol; water View Scheme
参考文献
Journal of the Chemical Society, , p. 3259,3262
参考文献
Justus Liebigs Annalen der Chemie, , vol. 278, p. 270
Justus Liebigs Annalen der Chemie, , vol. 295, p. 304,315
Justus Liebigs Annalen der Chemie, , vol. 278, p. 295
参考文献
Ach
Justus Liebigs Annalen der Chemie, 1889 , vol. 253, p. 56
Full Text Show Details
Claisen; Roosen
Justus Liebigs Annalen der Chemie, 1894 , vol. 278, p. 295
反应条件
1: 3-methyl-1-phenyl-1H-pyrazole-5-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=0 - 20°C; 3 h;
2: 1-(3-chloro-phenyl)-piperazine With triethylamine in tetrahydrofuran
T=20°C; 18 h;
参考文献
Aventis Pharma S. A.
Patent: US2005/130989 A1, 2005 ;
Location in patent: Page/Page column 12; 13 ;
