5-甲基-3-苯基-4-异恶唑甲酸合成路线 （共 35 条）
反应条件
1: 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid With thionyl chloride; N,N-dimethyl-formamide in 1,2-dichloro-ethane
2 h; Heating / reflux;
2: methylamine in ethanol; 1,2-dichloro-ethane
T=5°C;
参考文献
NOVARTIS AG
Patent: JP2005/501847 A, 2005 ;
Location in patent: Page/Page column 9 ;
反应条件
1: SOCl2 / 1,2-dichloro-ethane / 2 h / 80 °C
2: ethanol / 12 h / 0 - 20 °C
View Scheme
参考文献
Hintermann, Samuel; Chiesi, Michele; von Krosigk, Ulrike; Mathe, Daniele; Felber, Richard; Hengerer, Bastian
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 193 - 196
反应条件
1: (COCl)2, Py / hexane / 0.5 h / Ambient temperature
2: 3 h / Heating
View Scheme
参考文献
Dietliker,K. et al.
Helvetica Chimica Acta, 1976 , vol. 59, p. 2074 - 2099
反应条件
1: H2SO4, HNO3
2: H2 / PtO2 / ethanol / 760 Torr
View Scheme
参考文献
Doyle,F.P. et al.
Journal of the Chemical Society, 1963 , p. 5845 - 5854
反应条件
sulfuric acid; nitric acid
参考文献
Doyle,F.P. et al.
Journal of the Chemical Society, 1963 , p. 5845 - 5854
