5-甲基-3-苯基-4-异恶唑甲酸合成路线 （共 35 条）
反应条件
sodium hydroxide in methanol
参考文献
Green, Jeremy; Bemis, Guy; Grillot, Anne-Laure; Ledeboer, Mark; Salituro, Francesco G.; Harrington, Edmund; Gao, Huai; Baker, Christopher; Cao, Jingrong; Hale, Michael
Patent: US2003/149051 A1, 2003 ;
反应条件
sodium hydroxide in methanol
参考文献
Xin, Zhili; Zhao, Hongyu; Serby, Michael D.; Liu, Bo; Schaefer, Verlyn G.; Falls, Douglas H.; Kaszubska, Wiweka; Colins, Christine A.; Sham, Hing L.; Liu, Gang
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1201 - 1204
反应条件
1: benzaldehyde With hydroxylammonium sulfate in methanol T=20 - 40°C; 1 h; 2: With chlorine; sodium carbonate; triethylamine in methanol T=0 - 20°C; pH=~ 9.5; 24 h; Inert atmosphere; 3: acetoacetic acid methyl ester With sodium carbonate in methanol pH=~ 7 - 7.5;
参考文献
WO2012/164355 A1, ;
Page/Page column 12 ;
反应条件
2-nitrobenzeneboronic acid in 1,2-dichloro-ethane T=25°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Zheng, Hongchao; McDonald, Robert; Hall, Dennis G.
Chemistry - A European Journal, 2010 , vol. 16, # 18 p. 5454 - 5460
反应条件
1: NaOMe / methanol / 20 °C 2: 100 percent / aq. NaOH / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 4 p. 1201 - 1204
反应条件
1.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 1 h / 20 °C / pH 5 / Reflux 1.2: 20 °C 2.1: N-chloro-succinimide / dichloromethane / 0 - 20 °C 3.1: acetonitrile / 2 h / 0 °C 4.1: trifluoroacetic acid / 4 h / 20 °C View Scheme
反应条件
1: N-chloro-succinimide / dichloromethane / 0 - 20 °C 2: acetonitrile / 2 h / 0 °C 3: trifluoroacetic acid / 4 h / 20 °C View Scheme
反应条件
potassium permanganate in acetone Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 16, # 1 p. 117 - 125
反应条件
1: 110 °C 2: aq. KOH 3: aq. KOH / 4 h / Heating View Scheme
参考文献
Chemische Berichte, , vol. 94, p. 1956 - 1965
反应条件
potassium permanganate
参考文献
Gazzetta Chimica Italiana, , vol. 68, p. 411,416
