1: With sodium tetrahydroborate; nickel dichloride in tetrahydrofuran; methanol T=0°C; 1.5 h; 2: With water; ammonium chloride in tetrahydrofuran; methanol
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2006/118749 A1, 2006 ;
Location in patent: Page/Page column 146 ;
WO 2006/118749 A1
1: 4-bromo-aniline With copper(l) iodide; (1S,2S)-1,2-diaminocyclohexane; sodium iodide in water T=120°C; 24 h; 2: thiophenol With copper(l) iodide; (1S,2S)-1,2-diaminocyclohexane in water T=120°C; Further stages.;
参考文献
Carril, Monica; SanMartin, Raul; Dominguez, Esther; Tellitu, Imanol
Chemistry - A European Journal, 2007 , vol. 13, # 18 p. 5100 - 5105
