1-甲基-3,4-二氢-1H-苯并[e][1,4]二氮杂卓-2,5-二酮合成路线 （共 9 条）
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 6 p. 719 - 721
反应条件
hydrogenchloride in N,N-dimethyl-formamide T=70°C; 12 h;
参考文献
Akssira; Boumzebra; Kasmi; Dahdouh; Roumestant; Viallefont
Tetrahedron, 1994 , vol. 50, # 30 p. 9051 - 9060
反应条件
1: CH2Cl2 2: aq. NaOH / 0 °C 3: NH3 / methanol View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 13, # 2 p. 179 - 183
反应条件
1: DCC, DMAP / CH2Cl2 2: 69 percent / HCl / dimethylformamide / 12 h / 70 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 30 p. 9051 - 9060
反应条件
acetic acid 4 h; Heating;
参考文献
Mohiuddin, G.; Reddy, P. S. N.; Ahmed, Khalil; Ratnam, C. V.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 905 - 907
参考文献
Fryer; Pinto; Upasani
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 945 - 951
反应条件
hydrogenchloride; 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide 1.) 2 h, 0 deg C; 4 h, room temp., 2.) DMF, 4 h, 60 deg C; Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 50, # 30 p. 9051 - 9060
反应条件
1: 80 percent / POCl3; N,N-dimethylaniline / benzene / 7 h / Heating
2: 99 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / 2 h / 80 °C
View Scheme
参考文献
Nadin, Alan; Sanchez Lopez, Jose M.; Owens, Andrew P.; Howells, Dean M.; Talbot, Adam C.; Harrison, Timothy
Journal of Organic Chemistry, 2003 , vol. 68, # 7 p. 2844 - 2852
