2,6-二羟基-5-氟-3-氰基吡啶合成路线 （共 4 条）
反应条件
sodium ethanolate in ethanol 0.25 h; Heating; Yield given;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 35, # 6 p. 2280 - 2285
反应条件
1: 5-fluoro-2,6-dihydroxynicotinonitrile With phosphorus pentachloride; trichlorophosphate Heating / reflux; 2: malonic acid ethyl ester monopotassium salt With zinc(II) chloride in 1,2-dichloro-ethane Heating / reflux; 3: With hydrogenchloride; water in 1,2-dichloro-ethane T=90°C; 4 h; Product distribution / selectivity;
参考文献
LG LIFE SCIENCES LTD.
Patent: WO2007/64077 A1, 2007 ;
Location in patent: Page/Page column 6 ;
反应条件
trichlorophosphate in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane
