3,5-二甲氧基苯甲酸合成路线 （共 127 条）
反应条件
n-butyllithium; potassium tert-butylate in tetrahydrofuran; hexane T=-78°C; Methylation; 1.66667 h;
参考文献
Sinha, Surajit; Mandal, Bhubaneswar; Chandrasekaran, Srinivasan
Tetrahedron Letters, 2000 , vol. 41, # 17 p. 3157 - 3160
反应条件
1.1: oxalyl chloride / CH2Cl2; dimethylformamide / 1 h / Heating 2.1: 11.86 g / pyridine / CH2Cl2 / 0 - 20 °C 3.1: Mg / tetrahydrofuran / 0.5 h / 20 °C 3.2: 90 percent / tetrahydrofuran / 1.5 h / 0 °C 4.1: TiCl4 / CH2Cl2 / 0.33 h / -30 °C 4.2: 59 percent / CH2Cl2 / -45 - 20 °C View Scheme
参考文献
Harrington, Paul E.; Stergiades, Ioanna A.; Erickson, Joy; Makriyannis, Alexandros; Tius, Marcus A.
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6576 - 6582
反应条件
1: oxalyl chloride / CH2Cl2; dimethylformamide / 1 h / Heating 2: 11.86 g / pyridine / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Harrington, Paul E.; Stergiades, Ioanna A.; Erickson, Joy; Makriyannis, Alexandros; Tius, Marcus A.
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6576 - 6582
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1658 - 1666
反应条件
1: SOCl2 2: 92 percent / LiAlH4 / diethyl ether 3: 94 percent / PBr3 / CH2Cl2 4: 95 percent / 130 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 47, # 3 p. 167 - 174
反应条件
1: 99 percent / thionyl chloride / dimethylformamide / 18 h / Heating 2: 60 percent / AIBN, CBrCl3, 2-mercaptopyridine N-oxide sodium salt / 0.25 h / Heating 3: 78 percent / BBr3 / CH2Cl2 / -78 °C / to RT View Scheme
参考文献
Dol, Georg C.; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.
European Journal of Organic Chemistry, 1998 , # 2 p. 359 - 364
反应条件
1-trans-IODO-4-CYCLOHEXYL in N,N-dimethyl-formamide 3 h; Heating;
参考文献
Zuo, Li; Yao, Shanyan; Wang, Wei; Duan, Wenhu
Tetrahedron Letters, 2008 , vol. 49, # 25 p. 4054 - 4056
反应条件
1: LiAlH4 2: PBr3 3: CuI 4: aq. HCl, Py 5: oxalic acid View Scheme
参考文献
Petrzilka,T. et al.
Helvetica Chimica Acta, 1969 , vol. 52, # 4 p. 1102 - 1134
反应条件
1.1: LiAlH4 / tetrahydrofuran / 3 h / 20 °C 1.2: 97 percent / Na/K tartrate / tetrahydrofuran / 1 h / 20 °C 2.1: 86 percent / PBr3 / CH2Cl2 / 1 h / 20 °C 3.1: 83 percent / dimethylformamide / 1 h View Scheme
参考文献
Kingston; Weiler
Canadian Journal of Chemistry, 1977 , vol. 55, # 5 p. 785 - 791
反应条件
4: 28.8 g / fluoroboric acid, sodium nitrite / H2O 5: 7.6 g / warming, distillation 6: 1.) lithium / 1.) ether, 2 h 7: decarboxylation 8: boron tribromide, pyridine hydrochloride / CH2Cl2 / 24 h / -78 °C View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
