3,5-二甲氧基苯甲酸合成路线 （共 127 条）
反应条件
4: 28.8 g / fluoroboric acid, sodium nitrite / H2O 5: 7.6 g / warming, distillation 6: 52 percent / lithium chips / 0.75 h 7: boron tribromide, pyridine hydrochloride / CH2Cl2 / 24 h / -78 °C View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: 89 percent / (COCl)2 / benzene / 2 h, room t., 1 h, reflux 2: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight 3: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux 4: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature 5: NaI, ClSiMe3 / acetonitrile / 36 h / Heating View Scheme
参考文献
Petrzilka,T. et al.
Helvetica Chimica Acta, 1969 , vol. 52, # 4 p. 1102 - 1134
反应条件
1: (i) SOCl2, (ii) /BRN= 511834/ 2: (i) Mg, Et2O, (ii) /BRN= 2105670/ 3: Py / CH2Cl2 View Scheme
参考文献
Birr,C. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 162 - 172
反应条件
1: (i) SOCl2, (ii) /BRN= 511834/ 2: (i) Mg, Et2O, (ii) /BRN= 2105670/ View Scheme
参考文献
Birr,C. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 162 - 172
反应条件
1: 89 percent / (COCl)2 / benzene / 2 h, room t., 1 h, reflux 2: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight 3: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
1: 81.8 percent / H2SO4 2: 93.3 percent / N2H4*H2O / 3 h / Heating View Scheme
参考文献
Kumar, Davinder; Kapoor, Archana; Thangadurai, Ananda; Kumar, Pradeep; Narasimhan, Balasubramanian
Chinese Chemical Letters, 2011 , vol. 22, # 11 p. 1293 - 1296
反应条件
1: 1 M B2H6 / tetrahydrofuran 2: pyridine / benzene / Ambient temperature 3: 5 percent Chromat. / Irradiation View Scheme
参考文献
Pincock, J. A.; Wedge, P. J.
Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5587 - 5595
反应条件
1.1: 81.8 percent / H2SO4 2.1: 93.3 percent / N2H4*H2O / 3 h / Heating 3.1: 75.4 percent / K3[Fe(CN)6]; PEG-400; NH3 / toluene; H2O / 4 h / 10 - 20 °C 4.1: NaOMe; tetrabutylammonium iodide / dimethylformamide / 1 h / 20 °C 4.2: 60.7 percent / dimethylformamide / 8 h / 40 °C 5.1: 90 percent / BBr3 / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Shen, Zhen Lu; Zhuo, Guang Lan; Jiang, Xuan Zhen
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 11 p. 2395 - 2398
反应条件
1: 2.) trimethylchlorosilane, 3.) 0.5 N HCl 2: 1.) LDA, 2.) diethyl chlorophosphate, 3.) LDA View Scheme
参考文献
Busch-Petersen, Jakob; Hill, W. Adam; Fan, Pusheng; Khanolkar, Atmaram; Xie, Xuang-Qun; Tius, Marcus A.; Makriyannis, Alexandros
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3790 - 3796
反应条件
1: 1 M B2H6 / tetrahydrofuran 2: pyridine / benzene / Ambient temperature 3: 2 percent Chromat. / Irradiation View Scheme
参考文献
Petrzilka,T. et al.
Helvetica Chimica Acta, 1969 , vol. 52, # 4 p. 1102 - 1134
