3,5-二甲氧基苯甲酸合成路线 （共 127 条）
反应条件
4: 28.8 g / fluoroboric acid, sodium nitrite / H2O
5: 7.6 g / warming, distillation
6: 1.456 g / boron tribromide / CH2Cl2 / 52 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: sulfuric acid / 20 h / 0 °C / Reflux
2: sodium tetrahydroborate / tetrahydrofuran; methanol / 1.67 h / Reflux
3: manganese(IV) oxide / toluene / 15 h / Reflux
4: 1,3-dibromo-5,5-dimethyl-hydantoin / chloroform / 0 - 20 °C
View Scheme
参考文献
Takada, Akiomi; Hashimoto, Yoshimitsu; Takikawa, Hiroshi; Hikita, Katsuyoshi; Suzuki, Keisuke
Angewandte Chemie - International Edition, 2011 , vol. 50, # 10 p. 2297 - 2301
反应条件
1: 89 percent / (COCl)2 / benzene / 2 h, room t., 1 h, reflux
2: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight
3: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
4: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
5: ethanethiol, NaH / dimethylformamide / 3 h / Heating
View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
1: 89 percent / (COCl)2 / benzene / 2 h, room t., 1 h, reflux
2: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight
3: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
4: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
5: ethanethiol, NaH / dimethylformamide / 3 h / Heating
View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
1: 84 percent / DCC, DMAP / CH2Cl2 / 24 h / Ambient temperature
2: 99 percent / NaBH3CN, AcOH, HCl, H2O / tetrahydrofuran / 1 h / Ambient temperature
3: 95 percent / acetonitrile / 1.) reflux, 3 h, 2.) r.t., overnight
4: DCC, DMAP / CH2Cl2 / Ambient temperature
5: Et3N / dioxane / 12 h / Heating
6: 92 percent / KOH / ethanol / 2 h / Heating
7: 93 percent / imidazole / dimethylformamide / 24 h / Ambient temperature
9: Ph2PLi / tetrahydrofuran; hexane / 16 h / Heating
10: Bu4NF / tetrahydrofuran / Ambient temperature
View Scheme
参考文献
McAllister, Graeme D.; Hartley, Richard C.; Dawson, Michael J.; Knaggs, Andrew R.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 20 p. 3453 - 3457
反应条件
1: 87 percent / HNO3, acetic anhydride / acetic acid
2: 69 percent / FeSO4, NH3
View Scheme
参考文献
Insole, Joan M.
Journal of Chemical Research, Miniprint, 1990 , # 12 p. 2831 - 2867
反应条件
trichlorophosphate
4 h; Heating;
参考文献
Robertson; Beedle; Krushinski; Pollock; Wilson; Wyss; Hayes
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 717 - 727
反应条件
sulfuric acid; acetic acid
T=50°C; 5 h;
参考文献
Ni, Jizhi; Xiao, Heping; Weng, Lipeng; Wei, Xiaofeng; Xu, Youjun
Tetrahedron, 2011 , vol. 67, # 29 p. 5162 - 5167
反应条件
1: phosphorus pentachloride
2: carbon disulfide; aluminium chloride
View Scheme
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1913 , vol. <2> 87, p. 415
反应条件
1: hydrochloric acid
2: sodium; sodium ethylate
View Scheme
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
US 20120277224 A1
