3,5-二甲氧基苯甲酸合成路线 （共 127 条）
反应条件
4: 28.8 g / fluoroboric acid, sodium nitrite / H2O
5: 7.6 g / warming, distillation
6: 1.) lithium / 1.) ether, 2 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: 3,5-(MeO)2C6H3COOH With sodium in ammonia
Birch reduction;
2: isopropyl bromide in ammonia
参考文献
Castanedo, Ricardo; Covarrubias-Zuniga, Adrian; Maldonado, Luis A.
Tetrahedron Letters, 2006 , vol. 47, # 6 p. 973 - 976
反应条件
ammonia; lithium
1.) THF, -78 deg C, 2.) THF, -78 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Liepa, Andris J.; Wilkie, John S.; Winzenberg, Kevin N.
Australian Journal of Chemistry, 1989 , vol. 42, # 8 p. 1217 - 1225
反应条件
4: 28.8 g / fluoroboric acid, sodium nitrite / H2O
5: 7.6 g / warming, distillation
6: 1.) lithium / 1.) ether, 2 h
7: decarboxylation
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: LiAlH4
2: PBr3
3: CuI
4: aq. HCl, Py
5: oxalic acid
View Scheme
参考文献
Petrzilka,T. et al.
Helvetica Chimica Acta, 1969 , vol. 52, # 4 p. 1102 - 1134
反应条件
1: acetonitrile / 1 h / 20 °C
2: hydroxylamine / acetonitrile; water / 14 h / 23 °C
View Scheme
参考文献
Yoganathan, Sabesan; Miller, Scott J.
Organic Letters, 2013 , vol. 15, # 3 p. 602 - 605
反应条件
1: SOCl2
2: H2, quinoline, sulfur / Pd-BaSO4 / xylene
3: I2, HgO / benzene
View Scheme
参考文献
Dallacker,F.; Leidig,H.
Chemische Berichte, 1979 , vol. 112, # 7 p. 2672 - 2679
反应条件
1: 1 M B2H6 / tetrahydrofuran
2: pyridine / benzene / Ambient temperature
3: 56 percent Chromat. / Irradiation
View Scheme
参考文献
Pincock, J. A.; Wedge, P. J.
Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5587 - 5595
反应条件
1: 87 percent / SOCl2, pyridine / tetrahydrofuran
2: 2) Ag2O, H2O / 1) Et2O
3: 98 percent / LiAlH4 / tetrahydrofuran / Heating
View Scheme
参考文献
Almeida, Wanda P.; Correia, Carlos Roque D.
Tetrahedron Letters, 1994 , vol. 35, # 9 p. 1367 - 1370
反应条件
1: With oxalyl dichloride in acetone; toluene
Acylation; Heating;
2: With sodium azide in water; acetone
Substitution; 12 h; Further stages.;
参考文献
Uccello-Barretta, Gloria; Balzano, Federica; Quintavalli, Cristiana; Salvadori, Piero
Journal of Organic Chemistry, 2000 , vol. 65, # 12 p. 3596 - 3602
