N-(2,6-二甲基苯基)氯乙酰胺合成路线 （共 36 条）
反应条件
hydrogenchloride; sodium hydroxide; methylamine in tetrahydrofuran; ethyl acetate
参考文献
Theravance, Inc.
Patent: US6462034 B1, 2002 ;
US 6462034 B1
反应条件
in tetrahydrofuran
T=0°C;
参考文献
Advanced Medicine, Inc.
Patent: US6337423 B1, 2002 ;
Location in patent: Example 6 ;
US 6337423 B1
参考文献
Arya,V.P. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1977 , vol. 15, p. 133 - 140
反应条件
sodium iodide in acetone
10 h; Heating;
参考文献
Dumitrascu, Florea; Mitan, Carmen Irena; Draghici, Constantin; Caproiu, Miron Teodor; Caprau, Delia; Dumitrescu, Denisa
Revue Roumaine de Chimie, 2002 , vol. 47, # 3-4 p. 309 - 314
反应条件
in ethanol; water
T=90 - 95°C; 5 h;
参考文献
Mikiciuk-Olasik, Elzbieta; Wojewoda, Emilia; Bilichowski, Ireneusz; Witczak, Malgorzata; Karwowski, Boleslaw; Wagrowska-Danilewicz, Malgorzata; Stasikowska, Olga
Acta Poloniae Pharmaceutica - Drug Research, 2010 , vol. 67, # 2 p. 119 - 127
参考文献
Astra Pharmaceutical Products, Inc.
Patent: US4022899 A1, 1977 ;
