1: malonic acid dimethyl ester With sodium methylate in methanol 0.5 h; 2: Cyanocarbamidomethylenecyclohexane in methanol T=30°C; 2 h; 3: With hydrogenchloride; methanol; sodium hydroxide; water Product distribution / selectivity; more than 3 stages;
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; RefluxInert atmosphere;
参考文献
Wang, Jun; Cady, Sarah D.; Balannik, Victoria; Pinto, Lawrence H.; DeGrado, William F.; Hong, Mei
Journal of the American Chemical Society, 2009 , vol. 131, p. 8066 - 8076