N-(5-甲氨基-2-噻吩甲酰基)-L-谷氨酸二乙酯合成路线 （共 15 条）
反应条件
1: 59.8 percent / dicyclohexylcarbodiimide / tetrahydrofuran / 20 °C 2: 55.8 percent / diphenylphosphoryl azide; triethylamine / 7 h / Heating 3: 90.4 percent / tetrabutylammonium bromide; K2CO3; NaOH / ethyl acetate / 0.17 h / 20 °C 4: 91.1 percent / trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 33, # 20 p. 3519 - 3526
反应条件
1: 55.8 percent / diphenylphosphoryl azide; triethylamine / 7 h / Heating 2: 90.4 percent / tetrabutylammonium bromide; K2CO3; NaOH / ethyl acetate / 0.17 h / 20 °C 3: 91.1 percent / trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 33, # 20 p. 3519 - 3526
反应条件
1: 90.4 percent / tetrabutylammonium bromide; K2CO3; NaOH / ethyl acetate / 0.17 h / 20 °C 2: 91.1 percent / trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 33, # 20 p. 3519 - 3526
反应条件
1: 74.2 percent / 2,6-lutidine / dimethylformamide / 55 - 60 °C 2: 88.6 percent / 1 N aq. NaOH / ethanol / 2 h / 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 33, # 20 p. 3519 - 3526
反应条件
2,6-dimethylpyridine in N,N-dimethyl-formamide T=55 - 60°C;
参考文献
Cao, Sheng-Li; Wan, Rong; Feng, Yu-Ping
Synthetic Communications, 2003 , vol. 33, # 20 p. 3519 - 3526
