4-氨基-5-氯-2-乙氧基-N-[[4-(苯基甲基)吗啉-2-基]甲基]苯甲酰胺合成路线 (共 7 条)
反应条件
1: 1.) H2, acetic acid / 1.) Raney nickel / 1.) 95 percent EtOH, RT, 2.) CHCl3, RT, 2 h 2: 100 percent / 10percent HCl / 4 h / Heating 3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1406 - 1413
反应条件
1: 3 h / 80 °C 2: concd. H2SO4 / 1 h / 150 °C 3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1406 - 1413
反应条件
1: 83 percent / dimethylformamide / 5 h / Heating 2: 88 percent / 85percent hydrazine monohydrate / ethanol / 0.5 h / Heating 3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1406 - 1413
反应条件
1: 100 percent / 10percent HCl / 4 h / Heating 2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1406 - 1413
反应条件
1: 83 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 1.5 h / Ambient temperature 2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1406 - 1413
反应条件
1: 88 percent / 85percent hydrazine monohydrate / ethanol / 0.5 h / Heating 2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1406 - 1413
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane 4 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1406 - 1413