(2R,3S)-(-)-N-Boc-2,3-二苯基-6-氧代吗啉合成路线 （共 9 条）
反应条件
toluene-4-sulfonic acid; calcium chloride in benzene 8 h; Heating;
参考文献
Williams, Robert M.; Sinclair, Peter J.; Zhai, Dongguan; Chen, Daimo
Journal of the American Chemical Society, 1988 , vol. 110, # 5 p. 1547 - 1557
反应条件
1: Et3N / tetrahydrofuran / 1 h / 20 °C 2: toluene / 10 h / Heating 3: p-TsOH*H2O / toluene View Scheme
参考文献
Synlett, , # 4 art. no. Y04304ST, p. 693 - 696
反应条件
1: in toluene T=110°C; 13 h; 2: With toluene-4-sulfonic acid in toluene T=110°C; 1 h;
参考文献
Yeo, David J.; Warriner, Stuart L.; Wilson, Andrew J.
Chemical Communications, 2013 , vol. 49, # 80 p. 9131 - 9133
反应条件
1: toluene / 10 h / Heating 2: p-TsOH*H2O / toluene View Scheme
参考文献
Synlett, , # 4 art. no. Y04304ST, p. 693 - 696
反应条件
1: NaHCO3, NaCl / CHCl3; H2O / 20 h / Heating 2: 73.4 percent / p-toluenesulfonic acid monohydrate, CaCl2 / benzene / 8 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 110, # 5 p. 1547 - 1557
反应条件
1: N-bromosuccinimide / CCl4 / 1 h / Heating 2: 63 percent / ZnCl2 / tetrahydrofuran / 4 h 3: 71 percent / Li, NH3 / ethanol; tetrahydrofuran / 0.25 h / -33 °C View Scheme
参考文献
Williams, Robert M.; Im, Myeong-Nyeo
Tetrahedron Letters, 1988 , vol. 29, # 41 p. 6075 - 6078
反应条件
triethylamine; trifluoroacetic acid 1) CH2Cl2, rt, 6 h, 2) rt, 20 min; Yield given. Multistep reaction;
参考文献
Sebahar, Paul R; Osada, Hiroyuki; Usui, Takeo; Williams, Robert M
Tetrahedron, 2002 , vol. 58, # 32 p. 6311 - 6322
反应条件
1: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -82 deg C, 35 min, 2.) THF, -82 deg C, 1.5 h 2: 54 percent / Li, NH3(liquid), ethanol / tetrahydrofuran / 1 h / -33 °C View Scheme
参考文献
Williams, Robert M.; Im, Myeong-Nyeo
Tetrahedron Letters, 1988 , vol. 29, # 41 p. 6075 - 6078
反应条件
N-bromosuccinmide in tetrachloromethane 1 h; Heating;
参考文献
Journal of the American Chemical Society, , vol. 113, # 23 p. 8796 - 8806
