1: 4-chloro-2-fluoro-1-methoxybenzene With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78 - -55°C; 1 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; n-heptane; ethylbenzene T=-78 - -10°C; 3: With water; ammonium chloride in tetrahydrofuran; n-heptane; ethylbenzene Cooling with ice;

1: Cl2 / acetic acid / 4 h 2: 1.) sec-butyl-lithium / 1.) THF, -40 deg C, 15 min, 2.) THF, from -40 deg C to RT View Scheme

sec.-butyllithium 1.) THF, -40 deg C, 15 min, 2.) THF, from -40 deg C to RT; Yield given. Multistep reaction;