5-(2-环氧乙烷基)-8-(苯基甲氧基)-2(1H)-喹啉酮合成路线 （共 11 条）
反应条件
sodium hydroxide in DMF (N,N-dimethyl-formamide); water T=0°C; 2 h;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2005/277632 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
1: HCl 2: KOH / H2O 3: K2CO3; KI / methanol 4: H(1+) 5: LiAlBH4 / tetrahydrofuran 6: pyridine 7: KOtBu / 2-methyl-propan-2-ol View Scheme
参考文献
Naunyn-Schmiedeberg's Archives of Pharmacology, , vol. 359, # 3 p. 168 - 177
反应条件
1: HCl 2: KOH / H2O 3: K2CO3; KI / methanol 4: H(1+) 5: LiAlBH4 / tetrahydrofuran 6: pyridine 7: KOtBu / 2-methyl-propan-2-ol View Scheme
参考文献
Naunyn-Schmiedeberg's Archives of Pharmacology, , vol. 359, # 3 p. 168 - 177
反应条件
1: KOH / H2O 2: K2CO3; KI / methanol 3: H(1+) 4: LiAlBH4 / tetrahydrofuran 5: pyridine 6: KOtBu / 2-methyl-propan-2-ol View Scheme
参考文献
Naunyn-Schmiedeberg's Archives of Pharmacology, , vol. 359, # 3 p. 168 - 177
反应条件
1: K2CO3; KI / methanol 2: H(1+) 3: LiAlBH4 / tetrahydrofuran 4: pyridine 5: KOtBu / 2-methyl-propan-2-ol View Scheme
参考文献
Naunyn-Schmiedeberg's Archives of Pharmacology, , vol. 359, # 3 p. 168 - 177
反应条件
1: 1.) NaH / 1.) DMF, 45 min, 2.) DMF, 4 h 2: m-chloroperbenzoic acid / CH2Cl2 / 4 h / Ambient temperature 3: 55 percent / pyridinium chlorochromate / CH2Cl2 / 1 h 4: 1.98 g / Ac2O / 2.5 h / 50 °C 5: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 9 p. 1563 - 1566
反应条件
1: 1.) NaH / 1.) DMF, 45 min, 2.) DMF, 4 h 2: m-chloroperbenzoic acid / CH2Cl2 / 4 h / Ambient temperature 3: 55 percent / pyridinium chlorochromate / CH2Cl2 / 1 h 4: 1.98 g / Ac2O / 2.5 h / 50 °C 5: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 9 p. 1563 - 1566
反应条件
1: m-chloroperbenzoic acid / CH2Cl2 / 4 h / Ambient temperature 2: 55 percent / pyridinium chlorochromate / CH2Cl2 / 1 h 3: 1.98 g / Ac2O / 2.5 h / 50 °C 4: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 9 p. 1563 - 1566
反应条件
1: 55 percent / pyridinium chlorochromate / CH2Cl2 / 1 h 2: 1.98 g / Ac2O / 2.5 h / 50 °C 3: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 9 p. 1563 - 1566
反应条件
1: 1.98 g / Ac2O / 2.5 h / 50 °C 2: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 9 p. 1563 - 1566
