2,4-二甲基吡啶 1-氧化物合成路线 （共 19 条）
反应条件
3-chloro-benzenecarboperoxoic acid in chloroform T=20°C; 3 h;
参考文献
Tamura; Urano; Kikuchi; Higuchi; Hirobe; Nagano
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1514 - 1518
反应条件
1: aqueous HCl; chlorine; concentrated aqueous NH3 / Reaktion ueber 2 Stufen 2: aqueous H2O2; acetic acid 3: aqueous NaOH; acetone 4: aqueous NaOH 5: 130 °C View Scheme
参考文献
Naito; Dohmori
Pharmaceutical Bulletin, 1955 , vol. 3, p. 38,41
反应条件
potassium carbonate in 1,4-dioxane
参考文献
Korea Research Institute of Chemical Technology
Patent: US5889027 A1, 1999 ;
反应条件
1: 0.5 h / 110 - 120 °C 2: 1 mol/l aq. NaOH / methanol / 0.75 h / 20 °C 3: SOCl2 / CH2Cl2 / Heating View Scheme
参考文献
Weidmann, Klaus; Herling, Andreas W.; Lang, Hans-Jochen; Scheunemann, Karl-Heinz; Rippel, Robert; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 438 - 450
反应条件
in 1,2-dichloro-ethane Heating; MechanismProduct distribution;
参考文献
Wachi, Kazuyuki; Terada, Atsusuke
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3020 - 3028
反应条件
anschliessend Erhitzen mit wss. Salzsaeure;
参考文献
Furukawa
Pharmaceutical Bulletin, 1955 , vol. 3, p. 413,415
Yakugaku Zasshi, 1956 , vol. 76, p. 900
Chem.Abstr., 1957 , p. 2770
反应条件
1: N,N-dimethylcarbamoyl chloride / dichloromethane / |Inert atmosphere 2: water; potassium hydroxide / 4 h / |Reflux View Scheme
参考文献
Prat, Irene; Font, David; Company, Anna; Junge, Kathrin; Ribas, Xavi; Beller, Matthias; Costas, Miquel
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 5 p. 947 - 956
反应条件
1: CH2Cl2 / Heating 2: conc. HCl View Scheme
参考文献
Hagmann; Caldwell; Chen; Durette; Esser; Lanza; Kopka; Guthikonda; Shah; MacCoss; Chabin; Fletcher; Grant; Green; Humes; Kelly; Luell; Meurer; Moore; Pacholok; Pavia; Williams; Wong
Bioorganic and medicinal chemistry letters, 2000 , vol. 10, # 17 p. 1975 - 1978
反应条件
1: trifluoroacetic anhydride / dichloromethane / 84 h / 20 °C 2: selenium(IV) oxide / 1,4-dioxane / 3 h / 100 °C View Scheme
参考文献
Comba, Peter; Morgen, Michael; Wadepohl, Hubert
Inorganic Chemistry, 2013 , vol. 52, # 11 p. 6481 - 6501
反应条件
1: 71 percent / CH2Cl2 / 1.5 h 2: aq. ammonium persulfate / 1 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 28, # 20 p. 3817 - 3825
