1-苄基-3-羟基哌啶-3-羧酸甲酯合成路线 （共 5 条）
反应条件
hydrogenchloride in diethyl ether T=4°C; Yield given;
参考文献
Tsukamoto, Shin-ichi; Ichihara, Masato; Wanibuchi, Fumikazu; Usuda, Shinji; Hidaka, Kazuyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2292 - 2299
反应条件
1: 45.15 g / ZnI2 / CH2Cl2 / 2 h / Heating 2: 40.05 g / aq. HCl / 48 h / Ambient temperature 3: 10 percent / HCl / methanol / 5 deg C, 3 h -> room temperature, 18 h View Scheme
参考文献
Tsukamoto, Shin-ichi; Ichihara, Masato; Wanibuchi, Fumikazu; Usuda, Shinji; Hidaka, Kazuyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2292 - 2299
反应条件
hydrogenchloride in methanol 5 deg C, 3 h -> room temperature, 18 h;
参考文献
Saunders, John; Showell, Graham A.; Snow, Roger J; Baker, Raymond; Harley, Elizabeth A.; Freedman, Stephen B.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 486 - 491
反应条件
1: 40.05 g / aq. HCl / 48 h / Ambient temperature 2: 10 percent / HCl / methanol / 5 deg C, 3 h -> room temperature, 18 h View Scheme
参考文献
Saunders, John; Showell, Graham A.; Snow, Roger J; Baker, Raymond; Harley, Elizabeth A.; Freedman, Stephen B.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 486 - 491
反应条件
ammonia; ammonium formate; palladium 10 on activated carbon in ethanol; ethyl acetate T=80°C; 3 h;
参考文献
AiCuris GMBH and Co. KG
Patent: US2010/22527 A1, 2010 ;
Location in patent: Page/Page column 16 ;
US 20100022527 A1
