R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺合成路线 （共 23 条）
反应条件
1: With carbon in methanol T=20°C; 0.5 h; 2: With hydrogen; palladium 10 on activated carbon in methanol T=60 - 65°C; P=2942.29 - 3677.86 Torr; 3: With ammonia in water
参考文献
MATRIX LABORATORIES LTD
Patent: WO2008/152653 A2, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogen; 5 palladium on charcoal in methanol T=20°C; P=2206.72 Torr; 8 h;
参考文献
WO2012/101648 A1, ;
Page/Page column 7 ;
反应条件
water; potassium carbonate in methanol 8 h; Heating / reflux;
参考文献
LEK PHARMACEUTICALS D.D.
Patent: WO2005/63701 A1, 2005 ;
Location in patent: Page/Page column 13 ;
反应条件
sodium hydroxide in water T=20°C; pH=9.5 - 10; 1 h;
参考文献
WO2004/58694 A1, ;
Page 10 ;
反应条件
potassium carbonate in water T=20°C; 3 h;
参考文献
Sagratini, Gianni; Angeli, Piero; Buccioni, Michela; Gulini, Ugo; Marucci, Gabriella; Melchiorre, Carlo; Poggesi, Elena; Giardin, Dario
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5800 - 5807
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; 1 h; atmospheric pressure;
参考文献
Kim, Yongeun; Kang, Lae-Sung; Ha, Hyun-Joon; Ko, Seung Whan; Lee, Won Koo
Heterocycles, 2007 , vol. 71, # 10 p. 2243 - 2248
反应条件
ammonia in water T=0 - 25°C; pH=9.89 - 10.18; 1 h; Product distribution / selectivity;
参考文献
MEDICHEM, S.A.
Patent: WO2007/4077 A2, 2007 ;
Location in patent: Page/Page column 15; 19-20; 20-21 ;
反应条件
1: With hydrogenchloride; water 16 - 18 h; Heating / reflux; 2: With sodium carbonate in water pH=~ 10; 0.5 h; Product distribution / selectivity;
参考文献
ZENTIVA, A.S.
Patent: WO2005/75415 A1, 2005 ;
Location in patent: Page/Page column 13 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C; 1 h;
参考文献
Tetrahedron Asymmetry, , vol. 18, # 4 p. 488 - 492
反应条件
1: 88 percent / pyridine / 2 h / 20 °C 2: 63 percent / sodium azide / dimethylformamide / 2 h / 40 °C 3: H2 / Pd/C / ethanol / 1 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 4 p. 488 - 492
