1: With chlorosulfonic acid T=0 - 10°C; 1 h; 2: With sodium hydrogencarbonate in water; ethyl acetate T=25°C; 1 h; 3: With ammonia in tetrahydrofuran; water T=25°C; 1 h;

1: With hydrogenchloride; water 16 - 18 h; Heating / reflux; 2: With sodium carbonate in water pH=~ 10; 0.5 h; Product distribution / selectivity;