3-羟基-6-甲基吡啶合成路线 （共 103 条）
反应条件
1: 2-methyl-5-hydroxy-pyridine With sodium hydride in N,N-dimethyl-formamide
0.5 h; Cooling with ice;
2: benzyl chloride in N,N-dimethyl-formamide
T=20°C; 12 h;
参考文献
BANYU PHARMACEUTICAL CO.,LTD.; IINO, Tomoharu; ASAI, Masanori; OHNO, Akio; IF2; ISHIKAWA, Makoto; OHTAKE, Norikazu
Patent: WO2010/24110 A1, 2010 ;
Location in patent: Page/Page column 35 ;
WO 2010/024110 A1
反应条件
sodium hydroxide in water; acetone
16 h; Heating;
参考文献
Humphries, Paul S.; Almaden, Jonathon V.; Barnum, Sandra J.; Carlson, Thomas J.; Do, Quyen-Quyen T.; Fraser, James D.; Hess, Mary; Kim, Young H.; Ogilvie, Kathleen M.; Sun, Shaoxian
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 6116 - 6119
反应条件
calcium carbonate in N,N-dimethyl-formamide
参考文献
SHIONOGI and CO., LTD.
Patent: EP1297834 A1, 2003 ;
