甲基6-氨基-2-喹啉羧酸酯合成路线 （共 4 条）
反应条件
sulfuric acid in water
T=20°C; 20 h;
参考文献
Parker, Kathlyn A.; Mindt, Thomas L.
Organic Letters, 2002 , vol. 4, # 24 p. 4265 - 4268
反应条件
1: 1.) SeO2, tert-butyl hydroperoxide / 1.) methylene chloride, 40 deg C, 2 d, 2.) ether, THF
2: hydrogen / PtO2 / aq. ethanol; tetrahydrofuran / 2 h
View Scheme
参考文献
Warpehoski; Gebhard; Kelly; Krueger; Li; McGovren; Prairie; Wicnienski; Wierenga
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 590 - 603
反应条件
hydrogen; platinum(IV) oxide in tetrahydrofuran; ethanol
2 h; Title compound not separated from byproducts;
参考文献
Warpehoski; Gebhard; Kelly; Krueger; Li; McGovren; Prairie; Wicnienski; Wierenga
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 590 - 603
反应条件
1: 100 percent / cesium fluoride / dimethylformamide / 0.33 h / 20 °C
2: 80 percent / sulfuric acid / H2O / 20 h / 20 °C
View Scheme
参考文献
Parker, Kathlyn A.; Mindt, Thomas L.
Organic Letters, 2002 , vol. 4, # 24 p. 4265 - 4268
