4-氯-5,6,7,8-四氢喹唑啉-2-胺合成路线 （共 3 条）
反应条件
N,N-dimethyl-aniline; trichlorophosphate T=135 - 140°C; 1 h;
参考文献
Ohno; Mizukoshi; Komatsu; Kunoh; Nakamura; Katoh; Nagasaka
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 10 p. 4150 - 4165
反应条件
1: potassium tert-butylate / methanol / 23 - 60 °C 2: tetraethylammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 0.33 h / 110 °C View Scheme
参考文献
Savall, Brad M.; Chavez, Frank; Tays, Kevin; Dunford, Paul J.; Cowden, Jeffery M.; Hack, Michael D.; Wolin, Ronald L.; Thurmond, Robin L.; Edwards, James P.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2429 - 2439
反应条件
1: 1.) conc. HCl; 2.) 5percent NaOH / 1.) EtOH, reflux, 1.5 h; 2.) H2O, reflux, 1 h 2: 70 percent / POCl3, N,N-dimethylaniline / 1 h / 135 - 140 °C View Scheme
参考文献
Ohno; Mizukoshi; Komatsu; Kunoh; Nakamura; Katoh; Nagasaka
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 10 p. 4150 - 4165
