N-甲基-N-甲氧基胺盐酸盐合成路线 （共 166 条）
反应条件
pyridine in dichloromethane T=0 - 20°C; 3 h; Inert atmosphere;
参考文献
Trabbic, Christopher J.; Dietsch, Heather M.; Alexander, Evan M.; Nagy, Peter I.; Robinson, Michael W.; Overmeyer, Jean H.; Maltese, William A.; Erhardt, Paul W.
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 1 p. 73 - 77
反应条件
1: hexane carboxylic acid With N-ethyl-N,N-diisopropylamine; [bis(2-methoxyethyl)amino]-sulfur trifluoride in N,N-dimethyl-formamide T=0°C; 0.25 h; 2: N,O-dimethyl-hydroxylamine in N,N-dimethyl-formamide T=0 - 20°C; 3 h; Further stages.;
参考文献
Tunoori, Ashok Rao; White, Jonathan M.; Georg, Gunda I.
Organic Letters, 2000 , vol. 2, # 25 p. 4091 - 4093
反应条件
in dichloromethane T=0 - 20°C; 3.25 h;
参考文献
White, Jonathan M.; Tunoori, Ashok Rao; Turunen, Brandon J.; Georg, Gunda I.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2573 - 2576
反应条件
1: 2-Chloropyridine-3-carboxylic acid With 1,1'-carbonyldiimidazole in DMF (N,N-dimethyl-formamide) T=20°C; 1.53333 h; 2: N,O-dimethyl-hydroxylamine in DMF (N,N-dimethyl-formamide) T=20°C; 6 h;
参考文献
WO2004/96794 A1, ;
Page 39 ;
WO 2004/096794 A1
反应条件
pyridine; 1,2-dichloro-ethane in tetrahydrofuran T=0 - 20°C; 24 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 57, p. 311 - 322
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 20°C;
参考文献
MERCK SHARP and DOHME CORP.; DWYER, Michael P; KEERTIKAR, Kartik M; COBURN, Craig A; WU, Hao; HU, Bin; ZHONG, Bin; ZHANG, Chengren; DAN, Zhigang; TONG, Ling; YU, Wensheng
Patent: WO2012/41227 A1, 2012 ;
Location in patent: Page/Page column 116 ;
WO 2012/041227 A1
反应条件
triethylamine in dichloromethane T=0 - 20°C; 1.25 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/19151 A1, 2005 ;
Location in patent: Page/Page column 252 ;
WO 2005/019151 A1
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Zhou, Jun; Li, Bo; Qian, Zhen-Chao; Shi, Bing-Feng
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 1038 - 1046
反应条件
triethylamine in chloroform T=20°C;
参考文献
Greig, Iain R.; Coste, Emmanuel; Ralston, Stuart H.; Van'T Hof, Rob J.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5548 - 5551
反应条件
pyridine in dichloromethane
参考文献
Gebauer, Julian; Dewi, Purnama; Blechert, Siegfried
Tetrahedron Letters, 2005 , vol. 46, # 1 p. 43 - 46
