5-氯-1-甲基-1H-吡唑-4-甲腈合成路线 （共 3 条）
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0 - 5°C; 2: With urea; copper(l) chloride in water T=0 - 20°C;
参考文献
RALLIS INDIA LIMITED; PALIMKAR, Sanjay Sambhajirao; PAWAR, Jivan Dhanraj; SANKAR, B; KADAM, Subhash Rajaram; HINDUPUR, Rama Mohan; PRABHU, Venkatesh M.; PATI, Hari Narayan; SUPHALA, Vadiraj Gopinath; MANE, Avinash Sheshrao
Patent: WO2014/2111 A1, 2014 ;
Location in patent: Page/Page column 38; 39 ;
反应条件
1: 5-Amino-1-methyl-1H-pyrazole-4-carbonitrile With hydrogenchloride; sodium nitrite in water T=0 - 20°C; 2: urea With copper(l) chloride in water T=0 - 20°C;
参考文献
RALLIS INDIA LIMITED; PALIMKAR, Sanjay Sambhajirao; PAWAR, Jivan Dhanraj; SANKAR, B; KADAM, Subhash Rajaram; HINDUPUR, Rama Mohan; PRABHU, Venkatesh M.; PATI, Hari Narayan; SUPHALA, Vadiraj Gopinath; MANE, Avinash Sheshrao
Patent: WO2014/2109 A1, 2014 ;
Location in patent: Page/Page column 97 ;
反应条件
hydrogenchloride; sodium nitrite; sulfur dioxide 1) < 10 deg C, 30 min, 2) CCl4, room temp., 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Yamamoto, Susumu; Morimoto, Katsushi; Sato, Toshiaki
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 6 p. 1545 - 1547
