咪唑并[1,2-a]吡啶-8-甲醇合成路线 （共 7 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 3 h;
参考文献
Universite D'Auvergne Clermont 1; Universite Francois Rabelais Tours; Katholieke Universiteit Leuven
Patent: US2010/93781 A1, 2010 ;
Location in patent: Page/Page column 19; 20 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether T=20°C; 6 h; Inert atmosphere; 2: With sodium hydroxide in tetrahydrofuran; diethyl ether; water T=0 - 20°C; 0.25 h;
参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102142 A1, 2013 ;
Location in patent: Paragraph 0155 ;
反应条件
sodium hydrogencarbonate in ethanol
参考文献
G. D. Searle and Co.
Patent: US4687775 A1, 1987 ;
反应条件
1: 86 percent / NaHCO3 / ethanol; H2O / 9 h / Heating 2: 82 percent / LiAlH4 / tetrahydrofuran / 3 h View Scheme
参考文献
Chezal; Moreau; Delmas; Gueiffier; Blache; Grassy; Lartigue; Chavignon; Teulade
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6576 - 6584
反应条件
1.1: sodium hydrogencarbonate / water; ethanol / 18 h / |Reflux; |Inert atmosphere 2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 6 h / 20 °C / |Inert atmosphere 2.2: 0.25 h / 0 - 20 °C View Scheme
参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102142 A1, 2013 ;
反应条件
manganese(IV) oxide in chloroform 1.5 h; Heating;
参考文献
Universite D'Auvergne Clermont 1; Universite Francois Rabelais Tours; Katholieke Universiteit Leuven
Patent: US2010/93781 A1, 2010 ;
Location in patent: Page/Page column 20; 21 ;
反应条件
thionyl chloride T=70 - 80°C; 8 h; Inert atmosphere;
参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102142 A1, 2013 ;
Location in patent: Paragraph 0156 ;
