3-(m-甲基苯基)-1-丙醇合成路线 （共 10 条）
反应条件
sulfuric acid; hydrogen bromide
参考文献
Journal of the American Chemical Society, , vol. 56, p. 959,961
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C; 1.5 h;
2: With water; ammonium chloride in tetrahydrofuran
参考文献
Taisho Pharmaceutical Co. Ltd.
Patent: EP1650202 A1, 2006 ;
Location in patent: Page/Page column 10-11 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
0.333333 h;
参考文献
Sheddan, Neil A.; Mulzer, Johann
Organic Letters, 2005 , vol. 7, # 23 p. 5115 - 5118
反应条件
1.1: potassium tert-butoxide / dimethylformamide / 1 h / 0 °C
1.2: 82 percent / dimethylformamide / 24 h / 20 °C
2.1: 92 percent / lithium aluminium hydride / tetrahydrofuran / 0.33 h
View Scheme
参考文献
Sheddan, Neil A.; Mulzer, Johann
Organic Letters, 2005 , vol. 7, # 23 p. 5115 - 5118
反应条件
1: H2 / 5percent Pd/C / methanol / 1 h / Ambient temperature
2: LiAlH4 / diethyl ether / 1 h / Heating
View Scheme
参考文献
Hashizume; Ito; Yamada; Nagashima; Kanao; Tomoda; Sunazuka; Kumagai; Omura
Chemical and pharmaceutical bulletin, 1994 , vol. 42, # 3 p. 512 - 520
反应条件
1: NaOCH3 / CH2Cl2 / Ambient temperature
2: H2 / 5percent Pd/C / methanol / 1 h / Ambient temperature
3: LiAlH4 / diethyl ether / 1 h / Heating
View Scheme
参考文献
Hashizume; Ito; Yamada; Nagashima; Kanao; Tomoda; Sunazuka; Kumagai; Omura
Chemical and pharmaceutical bulletin, 1994 , vol. 42, # 3 p. 512 - 520
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Oki; Iwamura
Bulletin of the Chemical Society of Japan, 1959 , vol. 32, p. 1135,1136
参考文献
Mousseron; Du
Bulletin de la Societe Chimique de France, 1948 , p. 91,92
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine
1.) CH2Cl2, -40 deg C, 25 min, 2.) CH2Cl2, -40 deg C, 5 min; Multistep reaction;
参考文献
Hashizume; Ito; Yamada; Nagashima; Kanao; Tomoda; Sunazuka; Kumagai; Omura
Chemical and pharmaceutical bulletin, 1994 , vol. 42, # 3 p. 512 - 520
反应条件
1: 56 percent / red P, iodine / 5 h / 145 - 150 °C / Heating
2: 42 percent / BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) 0 deg C, 30 min; 2.) 2 h, room temp.
3: 92 percent / AgOTf / CH2Cl2 / 20 h / Ambient temperature
View Scheme
参考文献
Manas, Abdul Rahman Bin; Smith, Robin A. J.
Tetrahedron, 1987 , vol. 43, # 8 p. 1847 - 1856
