1H-imidazole in N,N-dimethyl-formamide T=20°C; 1.5 h;

1: (E)-1-Thexyldimethylsilyloxy-3-iodo-2-methylprop-2-ene With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 2: oxirane in tetrahydrofuran T=-78 - 20°C; 2.5 h; Further stages.;

1.1: 86 percent / Et3N; DMAP / CH2Cl2 / 18 h / 0 - 20 °C 2.1: t-BuLi / tetrahydrofuran; pentane / -78 °C 2.2: 33 percent / tetrahydrofuran / 2.5 h / -78 - 20 °C View Scheme