5-(三氟甲基)-2,3-二氢-4H-苯并吡喃-4-酮合成路线 （共 4 条）
参考文献
BARBOSA, Joseph; CARSON, Kenneth Gordon; GARDYAN, Michael Walter; HEALY, Jason Patrick; HAN, Qiang; MABON, Ross; PABBA, Praveen; TARVER, JR., James; TERRANOVA, Kristen M.; TUNOORI, Ashok; XU, Xiaolian
Patent: US2012/302562 A1, 2012 ;
Location in patent: Page/Page column 12 ;
US 20120302562 A1
反应条件
sulfuric acid T=20°C; 0.5 h;
参考文献
Gomtsyan, Arthur; Bayburt, Erol K.; Schmidt, Robert G.; Lee, Chih-Hung; Brown, Brian S.; Jinkerson, Tammie K.; Koenig, John R.; Daanen, Jerome F.; Latshaw, Steven P.
Patent: US2006/128689 A1, 2006 ;
Location in patent: Page/Page column 24 ;
反应条件
1: 31 percent / NaOH / 1 h / Heating; pH 10.0 2: polyphosphoric acid / 5 h / 100 °C View Scheme
参考文献
Sarges; Schnur; Belletire; Peterson
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 230 - 243
反应条件
1.1: sodium hydroxide / 1 h / Reflux 1.2: 20 °C 2.1: polyphosphoric acid / 0.33 h / 100 °C View Scheme
参考文献
BARBOSA, Joseph; CARSON, Kenneth Gordon; GARDYAN, Michael Walter; HEALY, Jason Patrick; HAN, Qiang; MABON, Ross; PABBA, Praveen; TARVER, JR., James; TERRANOVA, Kristen M.; TUNOORI, Ashok; XU, Xiaolian
Patent: US2012/302562 A1, 2012 ;
US 20120302562 A1
