N,N-二苄基-L-苯丙氨酸苄酯合成路线 （共 9 条）
反应条件
potassium carbonate in water Heating;
参考文献
Journal of Organic Chemistry, , vol. 59, # 15 p. 4040 - 4041
反应条件
sodium hydroxide; potassium carbonate in ethanol; water 1.5 h; Heating;
参考文献
Helvetica Chimica Acta, , vol. 81, # 5 p. 845 - 852
反应条件
sodium iodide; potassium carbonate in N,N-dimethyl acetamide; water; ethyl acetate
反应条件
1.1: s-BuLi; TMEDA / diethyl ether; cyclohexane; hexane / 6 h / -78 °C 1.2: 59 percent / diethyl ether; cyclohexane; hexane / 12 h / -78 - 20 °C 2.1: 76 percent / LiAlH4 / diethyl ether / 24 h / Heating 3.1: 92 percent / H2 / Pd(OH)2/C / ethyl acetate / 24 h / 20 °C View Scheme
参考文献
Weber; Kolczewski; Froehlich; Hoppe
Synthesis, 1999 , # 9 p. 1593 - 1606
反应条件
1.1: sodium amide / acetonitrile; tert-butyl methyl ether / 2 h / 0 - 5 °C / |Large scale 1.2: 2 h / 25 °C / |Large scale 2.1: sodium tetrahydroborate; acetic acid / tetrahydrofuran / 15 h / 20 °C View Scheme
参考文献
Haight, Anthony R.; Stuk, Timothy L.; Allen, Michael S.; Bhagavatula, Lakshmi; Fitzgerald, Michael; Hannick, Steven M.; Kerdesky, Francis A.J.; Menzia, Jerome A.; Parekh, Shyamal I.; Robbins, Timothy A.; Scarpetti, David; Tien, Jien-Heh J.
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 94 - 100
反应条件
lithium aluminium tetrahydride in diethyl ether Ambient temperature;
参考文献
Christoffers, Jens
Helvetica Chimica Acta, 1998 , vol. 81, # 5 p. 845 - 852
反应条件
1.1: sodium amide / acetonitrile; tert-butyl methyl ether / 2 h / 0 - 5 °C / |Large scale 1.2: 2 h / 25 °C / |Large scale 2.1: sodium tetrahydroborate; acetic acid / tetrahydrofuran / 3.5 h / 20 °C 2.2: 4 h / 20 °C 2.3: 0.5 h / 20 °C View Scheme
参考文献
Haight, Anthony R.; Stuk, Timothy L.; Allen, Michael S.; Bhagavatula, Lakshmi; Fitzgerald, Michael; Hannick, Steven M.; Kerdesky, Francis A.J.; Menzia, Jerome A.; Parekh, Shyamal I.; Robbins, Timothy A.; Scarpetti, David; Tien, Jien-Heh J.
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 94 - 100
反应条件
sodium amide in tetrahydrofuran T=-40°C;
参考文献
Sham, Hing L.; Zhao, Chen; Li, Leping; Betebenner, David A.; Saldivar, Ayda; Vasavanonda, Sudthida; Kempf, Dale J.; Plattner, Jacob J.; Norbeck, Daniel W.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3101 - 3103
反应条件
1.1: sodium amide / acetonitrile; tert-butyl methyl ether / 2 h / 0 - 5 °C / |Large scale 1.2: 2 h / 25 °C / |Large scale 2.1: sodium tetrahydroborate; methanesulfonic acid; isopropyl alcohol / ethylene glycol dimethyl ether / 12 h / 0 - 10 °C 2.2: 0.5 h / 5 °C 2.3: 2 h / 10 - 20 °C View Scheme
参考文献
Haight, Anthony R.; Stuk, Timothy L.; Allen, Michael S.; Bhagavatula, Lakshmi; Fitzgerald, Michael; Hannick, Steven M.; Kerdesky, Francis A.J.; Menzia, Jerome A.; Parekh, Shyamal I.; Robbins, Timothy A.; Scarpetti, David; Tien, Jien-Heh J.
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 94 - 100
