反应条件
1: 93 percent / KOH / diethyl ether / 6 h 2: 81 percent / NaI / acetone / 24 h / Ambient temperature 3: 75 percent / tetrahydrofuran / 24 h / Ambient temperature 4: 1.) HCl, 2b.) 4 A sieves / 1.) methanol, 10 min, 2a.) 24 h, 2b.) 6 d 5: 1.) NaCNBH3, 2.) concd. HCl / 1.) MeOH, 48 h, 2.) THF, reflux, 45 min View Scheme
参考文献
Prugh; Hartman; Mallorga; McKeever; Michelson; Murcko; Schwam; Smith; Sondey; Springer; Sugrue
Journal of Medicinal Chemistry, 1991 , vol. 34, # 6 p. 1805 - 1818
