1: 1.) POCl3 / 1.) CH2Cl2, <10 deg C, 2.) room temp., 2 h 2: 95 percent / piperidine, AcOH / toluene / 3.5 h / Heating 3: H2, Et3N / 10percent Pd/C / Ambient temperature 4: 1.) CF3COOH / 1.) 10 min, 2.) 0 deg C, 10 min View Scheme

1: 95 percent / piperidine, AcOH / toluene / 3.5 h / Heating 2: H2, Et3N / 10percent Pd/C / Ambient temperature 3: 1.) CF3COOH / 1.) 10 min, 2.) 0 deg C, 10 min View Scheme

trifluoroacetic acid 1.) 10 min, 2.) 0 deg C, 10 min; Yield given. Multistep reaction;