1-(2-乙氧基-乙基)-2-哌啶-4-基-1H-苯并咪唑合成路线 （共 4 条）
反应条件
1: With hydrogenchloride; water
2: With sodium hydroxide in dichloromethane; water
参考文献
Lee, Chun-Ho; Khoo, Ja-Heouk; Kwon, Kyoung-Chan; Ju, Hyun
Patent: US2011/9636 A1, 2011 ;
Location in patent: Page/Page column 6 ;
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 20 °C
1.2: 16 h / 60 °C
2.1: hydrogenchloride; water / tetrahydrofuran / 1 h / Reflux
View Scheme
参考文献
Collier, Steven J.; Wu, Xiang; Poh, Zhiying; Rajkumar, Gurubatham Abraham; Yet, Larry
Synthetic Communications, 2011 , vol. 41, # 9 p. 1394 - 1402
反应条件
1.1: sodium hydroxide / 1,4-dioxane; water / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 20 °C
2.2: 16 h / 60 °C
3.1: hydrogenchloride; water / tetrahydrofuran / 1 h / Reflux
View Scheme
参考文献
Collier, Steven J.; Wu, Xiang; Poh, Zhiying; Rajkumar, Gurubatham Abraham; Yet, Larry
Synthetic Communications, 2011 , vol. 41, # 9 p. 1394 - 1402
反应条件
hydrogenchloride
15 h; Heating;
参考文献
Iemura; Kawashima; Fukuda; et al.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 1 p. 31 - 37
