Filitis, L. N.; Akalaeva, T. V.; Amel'kin, O. Yu.; Bokanov, A. I.; Ivanov, P. Yu.; Shvedov, V. I.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 10 p. 780 - 785
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 10 p. 1217 - 1222
1: 81.7 percent / SOCl2 / dimethylformamide; benzene / 2 h / 50 - 55 °C
2: NaBH4 / ethanol / 0.5 h / 0 - 5 °C
3: 68.4 percent / 50percent aq. NaOH / tetrabutylammonium bromide / benzene / 5 h / Ambient temperature
View Scheme
参考文献
Ivanov, P. Yu.; Alekseeva, L. M.; Bokanov, A. I.; Shvedov, V. I.; Sheinker, Yu. N.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 1 p. 62 - 65
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 1 p. 71 - 75
With thionyl chloride in N,N-dimethyl-formamide; benzene T=50 - 55°C; 2 h;
参考文献
Ivanov, P. Yu.; Alekseeva, L. M.; Bokanov, A. I.; Shvedov, V. I.; Sheinker, Yu. N. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 1 p. 62 - 65Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 1 p. 71 - 75
Multi-step reaction with 2 steps 1: 81.7 percent / SOCl2 / dimethylformamide; benzene / 2 h / 50 - 55 °C2: NaBH4 / ethanol / 0.5 h / 0 - 5 °C
参考文献
Ivanov, P. Yu.; Alekseeva, L. M.; Bokanov, A. I.; Shvedov, V. I.; Sheinker, Yu. N. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 1 p. 62 - 65Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 1 p. 71 - 75
