2-[(4-苄基-2-吗啉基)甲基]-1H-异吲哚-1,3(2H)-二酮合成路线 （共 6 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=120°C;
参考文献
HYUNDAI PHARM CO., LTD.; LEE, In Hee; PARK, Chang Min; KIM, Se Hoan; CHAE, Hee Il; PYEON, Doo Hyeok; SHIN, Myoung Hyeon; HWANG, Jeong Un; MOON, Soon Young; HA, Tae Young; KIM, So Youn; CHOI, Hyuk Joon; YOO, Myoung Hyun; LEE, Jong Chan; KIM, Young Seok; RHEE, Jae Keol
Patent: WO2012/128582 A2, 2012 ;
Location in patent: Page/Page column 109 ;
WO 2012/128582 A2
反应条件
1: 2.) concd. H2SO4 / 1.) RT, 3 h, 2.) 150 deg C, 1 h 2: 83 percent / dimethylformamide / 5 h / Heating View Scheme
参考文献
HYUNDAI PHARM CO., LTD.; LEE, In Hee; PARK, Chang Min; KIM, Se Hoan; CHAE, Hee Il; PYEON, Doo Hyeok; SHIN, Myoung Hyeon; HWANG, Jeong Un; MOON, Soon Young; HA, Tae Young; KIM, So Youn; CHOI, Hyuk Joon; YOO, Myoung Hyun; LEE, Jong Chan; KIM, Young Seok; RHEE, Jae Keol
Patent: WO2012/128582 A2, 2012 ;
WO 2012/128582 A2
反应条件
hydrazine hydrate in ethanol 0.5 h; Heating;
参考文献
Kato; Morie; Hino; Kon; Naruto; Yoshida; Karasawa; Matsumoto
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1406 - 1413
反应条件
1: 88 percent / 85percent hydrazine monohydrate / ethanol / 0.5 h / Heating 2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1406 - 1413
反应条件
1: 83.4 percent / hydrazine monohydrate / ethanol / 4 h / Heating 2: 82.3 percent / toluene / 3 h / Ambient temperature View Scheme
参考文献
Araki; Kuroda; Uemori; Moriguchi; Ikeda; Hirayama; Yokoyama; Iwao; Yakushiji
Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1356 - 1363
反应条件
1: 88 percent / 85percent hydrazine monohydrate / ethanol / 0.5 h / Heating 2: 1.) triethylamine, ethyl chloroformate / 1.) CHCl3, -10 deg C, 1 h, 2.)a) from -10 deg C to -5 deg C, 1 h, b) RT View Scheme
参考文献
Kato; Morie; Hino; Kon; Naruto; Yoshida; Karasawa; Matsumoto
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1406 - 1413
