8-氨基-4-氧代-4H-苯并吡喃-2-羧酸合成路线 （共 3 条）
反应条件
1: With potassium carbonate in tetrahydrofuran; ethanol; water T=20°C; 2: With hydrogenchloride in tetrahydrofuran; ethanol; water pH=<= 2;
参考文献
Funke, Mario; Thimm, Dominik; Schiedel, Anke C.; Mueller, Christa E.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5182 - 5197
反应条件
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 5 °C / |Inert atmosphere 1.2: |Inert atmosphere 2.1: hydrogenchloride / ethanol; water / |Inert atmosphere; |Reflux 3.1: SnCl2·2H2O; hydrogenchloride / ethanol; water / 65 - 70 °C 4.1: potassium carbonate / ethanol; water; tetrahydrofuran / 20 °C 4.2: pH <= 2 View Scheme
参考文献
Funke, Mario; Thimm, Dominik; Schiedel, Anke C.; Mueller, Christa E.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5182 - 5197
反应条件
1.1: SnCl2·2H2O; hydrogenchloride / ethanol; water / 65 - 70 °C 2.1: potassium carbonate / ethanol; water; tetrahydrofuran / 20 °C 2.2: pH <= 2 View Scheme
参考文献
Funke, Mario; Thimm, Dominik; Schiedel, Anke C.; Mueller, Christa E.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5182 - 5197
