7-氯-6-硝基噻吩并[3,2-b]吡啶合成路线 (共 2 条)
反应条件
1: With trichlorophosphate 1 h; Heating / reflux; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
Pitts, William J.; Das, Jagabandhu; Qiu, Yuping; Spergel, Steven H.
Patent: US2006/178393 A1, 2006 ;
Location in patent: Page/Page column 28-29 ;
US 20060178393 A1
反应条件
1.1: tetra-n-butylammonium nitrate / dichloromethane / -5 °C 1.2: -5 - 20 °C 2.1: trichlorophosphate / 1 h / |Reflux View Scheme
参考文献
Incyte Corporation; Li, Yun-Long; Zhu, Wenyu; Mei, Song; Glenn, Joseph
Patent: US2014/121198 A1, 2014 ;