2-吡啶基硼酸 甲基亚氨基二乙酸酯合成路线 （共 11 条）
反应条件
in tetrahydrofuran; hexane; dimethyl sulfoxide T=110 - 120°C; Inert atmosphere;
参考文献
Burke, Martin D.; Dick, Graham R.; Knapp, David M.; Gillis, Eric P.; Klubnick, Jenna A.
Patent: US2011/201806 A1, 2011 ;
Location in patent: Page/Page column 11-12 ;
反应条件
1: 2-bromo-pyridine With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - 20°C; 2: MIDA in tetrahydrofuran; hexane; dimethyl sulfoxide T=75°C; P=1 Torr; 2 h;
参考文献
Knapp, David M.; Gillis, Eric P.; Burke, Martin D.
Journal of the American Chemical Society, 2009 , vol. 131, p. 6961 - 6963
反应条件
1.1: tetrahydrofuran / -78 °C / Inert atmosphere 1.2: -78 - 23 °C 2.1: hexane; dimethyl sulfoxide; tetrahydrofuran / 110 - 120 °C / Inert atmosphere View Scheme
反应条件
potassium phosphate; XPhos Palladacycle methyl t-butyl etherate; copper diacetate; bis-(2-hydroxy-ethyl)-amine in N,N-dimethyl-formamide T=100°C; 24 h; Inert atmosphere;
参考文献
Dick, Graham R.; Woerly, Eric M.; Burke, Martin D.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2667 - 2672
反应条件
potassium phosphate; XPhos Palladacycle methyl t-butyl etherate; copper diacetate; bis-(2-hydroxy-ethyl)-amine in N,N-dimethyl-formamide T=100°C; 24 h; Inert atmosphere;
参考文献
Dick, Graham R.; Woerly, Eric M.; Burke, Martin D.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2667 - 2672
反应条件
potassium phosphate; XPhos Palladacycle methyl t-butyl etherate; copper diacetate; bis-(2-hydroxy-ethyl)-amine in N,N-dimethyl-formamide T=100°C; 24 h; Inert atmosphere;
参考文献
Dick, Graham R.; Woerly, Eric M.; Burke, Martin D.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2667 - 2672
反应条件
potassium phosphate; XPhos Palladacycle methyl t-butyl etherate; copper diacetate; bis-(2-hydroxy-ethyl)-amine in N,N-dimethyl-formamide T=80°C; 24 h; Inert atmosphere;
参考文献
Dick, Graham R.; Woerly, Eric M.; Burke, Martin D.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2667 - 2672
反应条件
potassium phosphate; XPhos Palladacycle methyl t-butyl etherate; copper diacetate; bis-(2-hydroxy-ethyl)-amine in N,N-dimethyl-formamide T=100°C; 24 h; Inert atmosphere;
参考文献
Dick, Graham R.; Woerly, Eric M.; Burke, Martin D.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2667 - 2672
反应条件
potassium phosphate; XPhos Palladacycle methyl t-butyl etherate; copper diacetate; bis-(2-hydroxy-ethyl)-amine in N,N-dimethyl-formamide
T=100°C; 24 h; Inert atmosphere;
参考文献
Dick, Graham R.; Woerly, Eric M.; Burke, Martin D.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2667 - 2672
反应条件
potassium phosphate; XPhos Palladacycle methyl t-butyl etherate; copper diacetate; bis-(2-hydroxy-ethyl)-amine in N,N-dimethyl-formamide
T=100°C; 24 h; Inert atmosphere;
参考文献
Dick, Graham R.; Woerly, Eric M.; Burke, Martin D.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2667 - 2672
