hydrogenchloride in 1,4-dioxane 16 h; Ambient temperature;

1: 78 percent / 4 N aq. HCl / dioxane / 16 h / Ambient temperature 2: 96 percent / 1 N aq. NaOH / 16 h / Ambient temperature View Scheme

hydrogenchloride in 1,4-dioxane 16 h; Ambient temperature;

Multi-step reaction with 7 steps 1: 100 percent / p-toluenesulfonic acid*H2O / benzene / 5 h / Heating2: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr3: 86 percent / KOH / ethanol / 16 h / Ambient temperature4: 98 percent / conc. H2SO4 / 16 h / Ambient temperature5: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C6: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature7: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature  

Multi-step reaction with 6 steps 1: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr2: 86 percent / KOH / ethanol / 16 h / Ambient temperature3: 98 percent / conc. H2SO4 / 16 h / Ambient temperature4: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C5: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature6: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature  

Multi-step reaction with 5 steps 1: 64 percent / H2, AcOH / 5percent Pd/C / 5 h / 70 °C / 2280 Torr2: 69 percent / diphenyl phosphorazidate, N-methylmorpholine / dimethylformamide / 16 h / Ambient temperature3: 35 percent / 4 N aq. HCl / dioxane / 4 h / Ambient temperature4: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature5: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature  

Multi-step reaction with 5 steps 1: 86 percent / KOH / ethanol / 16 h / Ambient temperature2: 98 percent / conc. H2SO4 / 16 h / Ambient temperature3: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C4: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature5: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature