4-[(5R,10S,13R,14S,17R)-14-羟基-10,13-二甲基-3-氧代-2,4,5,6,7,8,9,11,12,15,16,17-十二氢-1H-环戊并[a]菲-17-基]-5H-呋喃-2-酮合成路线 （共 5 条）
→
1102-88-14-[(5R,10S,13R,14S,17R)-14-羟基-10,13-二甲基-3-氧代-2,4,5,6,7,8,9,11,12,15,16,17-十二氢-1H-环戊并[a]菲-17-基]-5H-呋喃-2-酮
反应条件
Jone's reagent in acetone T=0 - 20°C; Jones oxidation; 3 h;
参考文献
Jensen, Marie; Schmidt, Steffen; Fedosova, Natalya U.; Mollenhauer, Jan; Jensen, Henrik H.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 7 p. 2407 - 2417
→
1102-88-14-[(5R,10S,13R,14S,17R)-14-羟基-10,13-二甲基-3-氧代-2,4,5,6,7,8,9,11,12,15,16,17-十二氢-1H-环戊并[a]菲-17-基]-5H-呋喃-2-酮
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide 3 h; Ambient temperature;
参考文献
Frigerio, Marco; Santagostino, Marco
Tetrahedron Letters, 1994 , vol. 35, # 43 p. 8019 - 8022
→
1102-88-14-[(5R,10S,13R,14S,17R)-14-羟基-10,13-二甲基-3-氧代-2,4,5,6,7,8,9,11,12,15,16,17-十二氢-1H-环戊并[a]菲-17-基]-5H-呋喃-2-酮
反应条件
17-day-old Digitalis purpurea cell suspension cultures in various solvent(s) 120 h;
参考文献
Hirotani, Masao; Furuya, Tsutomu
Phytochemistry (Elsevier), 1980 , vol. 19, p. 531 - 534
→
1102-88-14-[(5R,10S,13R,14S,17R)-14-羟基-10,13-二甲基-3-氧代-2,4,5,6,7,8,9,11,12,15,16,17-十二氢-1H-环戊并[a]菲-17-基]-5H-呋喃-2-酮
反应条件
1: sulfuric acid; water / ethanol / 0.5 h / Reflux 2: pyridine; chromium(VI) oxide View Scheme
参考文献
Bose, Chandana
Asian Journal of Chemistry, 2011 , vol. 23, # 3 p. 1252 - 1254
→
1102-88-14-[(5R,10S,13R,14S,17R)-14-羟基-10,13-二甲基-3-氧代-2,4,5,6,7,8,9,11,12,15,16,17-十二氢-1H-环戊并[a]菲-17-基]-5H-呋喃-2-酮
反应条件
1: H2O 2: 15 g / CrO3; pyridine / CHCl3 / 10 h / 20 °C View Scheme
参考文献
Makarevich; Gubin; Megges
Chemistry of Natural Compounds, 2005 , vol. 41, # 1 p. 52 - 55
