EMD-1214063; 3-[1,6-二氢-1-[[3-[5-[(1-甲基-4-哌啶基)甲氧基]-2-嘧啶基]苯基]甲基]-6-氧代-3-哒嗪基]苯腈合成路线 (共 2 条)
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=20°C; Cooling with ice;
参考文献
MERCK PATENT GESELLSCHAFT
Patent: US2010/197690 A1, 2010 ;
Location in patent: Page/Page column 18 ;
反应条件
formic acid in water T=110°C; 2 h;
参考文献
MERCK PATENT GMBH; BECKER, Axel; KUEHN, Clemens; SAAL, Christoph; SCHADT, Oliver; DORSCH, Dieter; BOKEL, Heinz-Hermann; STIEBER, Frank; DONINI, Christina
Patent: WO2010/78897 A1, 2010 ;
Location in patent: Page/Page column 18 ;