5-[双(2-羟基乙基)氨基]-1-甲基-1H-苯并咪唑-2-丁酸甲酯合成路线 （共 8 条）
反应条件
1: With hydrogenchloride in methyl acetate; water T=73°C; 2.5 h; 2: With ammonia in methyl acetate; water pH=6.0;
参考文献
SYNTHON BV; BARTOS, Petr; BENOVSKY, Petr; BARTL, Jiri
Patent: WO2013/150020 A1, 2013 ;
Location in patent: Page/Page column 17-18 ;
反应条件
1: 82 percent / H2O / 5 h / 95 °C 2: 93 percent / CH3COONa*3H2O / H2O 3: methanol View Scheme
参考文献
Werner; Letsch; Ihn
Pharmazie, 1987 , vol. 42, # 4 p. 272 - 273
反应条件
1: 93 percent / CH3COONa*3H2O / H2O 2: methanol View Scheme
参考文献
Werner; Letsch; Ihn
Pharmazie, 1987 , vol. 42, # 4 p. 272 - 273
反应条件
1.1: water / 4.5 h / 70 °C 2.1: hydrogen; / ethanol / 2 h / 23 °C / 2585.81 - 3102.97 Torr / |Inert atmosphere 3.1: ethanol / 5 h / 23 °C / 2585.81 - 3102.97 Torr / |Inert atmosphere 4.1: hydrogenchloride / water; methyl acetate / 2.5 h / 73 °C 4.2: pH 6.0 View Scheme
参考文献
SYNTHON BV; BARTOS, Petr; BENOVSKY, Petr; BARTL, Jiri
Patent: WO2013/150020 A1, 2013 ;
反应条件
1.1: hydrogen; / ethanol / 2 h / 23 °C / 2585.81 - 3102.97 Torr / |Inert atmosphere 2.1: ethanol / 5 h / 23 °C / 2585.81 - 3102.97 Torr / |Inert atmosphere 3.1: hydrogenchloride / water; methyl acetate / 2.5 h / 73 °C 3.2: pH 6.0 View Scheme
参考文献
SYNTHON BV; BARTOS, Petr; BENOVSKY, Petr; BARTL, Jiri
Patent: WO2013/150020 A1, 2013 ;
参考文献
Werner; Letsch; Ihn
Pharmazie, 1987 , vol. 42, # 4 p. 272 - 273
反应条件
1: trichlorophosphate / 0.25 h / |Reflux 2: hydrogenchloride / water / 0.25 h / 25 - 28 °C View Scheme
反应条件
trichlorophosphate
0.25 h; Reflux;
参考文献
Arevipharma GmbH; Schickaneder, Helmut; Schickaneder, Christian; Limmert, Michael
Patent: US2013/184471 A1, 2013 ;
Location in patent: Paragraph 0146; 0147; 0148; 0149; 0150 ;
