(betaR)-beta-环戊基-4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-丙腈马来酸盐合成路线 (共 5 条)
反应条件
in isopropyl alcohol T=20°C; 2.5 h; Heating / reflux;
参考文献
US2008/312259 A1, ;
Page/Page column 6 ;
US 20080312259 A1
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C 2: ethanol; hexane / |Resolution of racemate 3: trifluoroacetic acid / dichloromethane / 6 h 4: isopropyl alcohol / 20 °C / |Heating View Scheme
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C 2: ethanol; hexane / |Resolution of racemate 3: trifluoroacetic acid / dichloromethane / 6 h 4: isopropyl alcohol / 20 °C / |Heating View Scheme
反应条件
1: ethanol; hexane / |Resolution of racemate 2: trifluoroacetic acid / dichloromethane / 6 h 3: isopropyl alcohol / 20 °C / |Heating View Scheme
反应条件
1: trifluoroacetic acid / dichloromethane / 6 h 2: isopropyl alcohol / 20 °C / |Heating View Scheme