(2R,8R,9S,10R,13S,14S,17S)-17-羟基-2,13-二甲基-2,6,7,8,9,10,11,12,14,15,16,17-十二氢-1H-环戊并[a]菲-3-酮合成路线 （共 5 条）
→
1092-04-2(2R,8R,9S,10R,13S,14S,17S)-17-羟基-2,13-二甲基-2,6,7,8,9,10,11,12,14,15,16,17-十二氢-1H-环戊并[a]菲-3-酮
反应条件
potassium hydroxide in methanol
参考文献
Yamato; Kaneko
Tetrahedron, 1965 , vol. 21, # 9 p. 2501 - 2508
→
1092-04-2(2R,8R,9S,10R,13S,14S,17S)-17-羟基-2,13-二甲基-2,6,7,8,9,10,11,12,14,15,16,17-十二氢-1H-环戊并[a]菲-3-酮
反应条件
1: (i) Li, EtOH, liq. NH3, Et2O, (ii) aq. HCl, MeOH 2: aq. KOH / methanol View Scheme
参考文献
Yamato; Kaneko
Tetrahedron, 1965 , vol. 21, # 9 p. 2501 - 2508
→
1092-04-2(2R,8R,9S,10R,13S,14S,17S)-17-羟基-2,13-二甲基-2,6,7,8,9,10,11,12,14,15,16,17-十二氢-1H-环戊并[a]菲-3-酮+
反应条件
(i) Li, EtOH, liq. NH3, Et2O, (ii) aq. HCl, MeOH; Multistep reaction;
参考文献
Yamato; Kaneko
Tetrahedron, 1965 , vol. 21, # 9 p. 2501 - 2508
→
1092-04-2(2R,8R,9S,10R,13S,14S,17S)-17-羟基-2,13-二甲基-2,6,7,8,9,10,11,12,14,15,16,17-十二氢-1H-环戊并[a]菲-3-酮
反应条件
(i) Li, liq. NH3, (ii) aq. HCl, MeOH; Multistep reaction;
参考文献
Kaneko,H. et al.
Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, # 2 p. 264 - 265
→
1092-04-2(2R,8R,9S,10R,13S,14S,17S)-17-羟基-2,13-二甲基-2,6,7,8,9,10,11,12,14,15,16,17-十二氢-1H-环戊并[a]菲-3-酮
反应条件
(i) (CO2Et)2, NaH, benzene, (ii) /BRN= 969135/, K2CO3, acetone, (iii) NaOEt, EtOH; Multistep reaction;
参考文献
Dutler,H. et al.
Helvetica Chimica Acta, 1962 , vol. 45, p. 2346 - 2381
