N,N-二甲基-3-氯丙胺合成路线 （共 146 条）
反应条件
1: 1-dimethylamino-3-chloropropane With iodine; magnesium in benzene 3.25 - 4.25 h; Heating / reflux; 2: diethyl phenyl orthoformate in benzene 3 h;
参考文献
NATCO PHARMA LIMITED
Patent: WO2003/101931 A2, 2003 ;
Location in patent: Page 19 ;
反应条件
hydrogenchloride; 1,1-dibromo ethane; magnesium 1) THF, reflux; 2) THF, reflux;; Yield given. Multistep reaction;
参考文献
Miodownik, A.; Kreisberger, J.; Nussim, M.; Avnir, D.
Synthetic Communications, 1981 , vol. 11, # 3 p. 241 - 246
反应条件
in anhydrous xylene; hexane; water
参考文献
Aziende Chimiche Riunute Angelini Francesco A.C.R.A.F. S.p.A.
Patent: US4749794 A1, 1988 ;
反应条件
ammonium acetate; potassium hydroxide; sodium hydrogencarbonate; potassium carbonate in methanol; ethanol; water; acetone; toluene
参考文献
Goedecke Aktiengesellschaft
Patent: US5380746 A1, 1995 ;
反应条件
1: 66 percent / NaH / dimethylformamide 2: 1.) 5 M KOH, 2.) AcONH4 / 1.) EtOH View Scheme
参考文献
Sasaki, Shigeki; Hashimoto, Tomohiro; Obana, Norihiro; Yasuda, Hideyo; Uehara, Yoshimasa; Maeda, Minoru
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 9 p. 1019 - 1022
反应条件
1: 1-dimethylamino-3-chloropropane With iodine; magnesium in tetrahydrofuran Heating; 2: 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one in tetrahydrofuran T=0 - 20°C; Grignard reaction; Further stages.;
参考文献
Hudgens, Debjani P.; Taylor, Catherine; Batts, Timothy W.; Patel, Manoj K.; Brown, Milton L.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8366 - 8378
反应条件
sodium amide; toluene
参考文献
Chan, Cecil; Yin, Hong; Garforth, Jacqui; McKie, James H.; Jaouhari, Rabih; Speers, Peter; Douglas, Kenneth T.; Rock, Peter J.; Yardley, Vanessa; Croft, Simon L.; Fairlamb, Alan H.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 2 p. 148 - 156
参考文献
Schmitt et al.
Bulletin de la Societe Chimique de France, 1957 , p. 1474,1480
反应条件
sodium amide; toluene
参考文献
Schmitt et al.
Bulletin de la Societe Chimique de France, 1957 , p. 1474,1480
反应条件
(i) aq. Na2S2O3, MeOH, (ii) I2; Multistep reaction;
参考文献
Ekambaram,A. et al.
Journal of Organic Chemistry, 1967 , vol. 32, p. 2985 - 2987
